McCaffrey’s health is the central variable. Wilson’s fantasy upside depends on McCaffrey’s availability; if McCaffrey is limited or out, Wilson and Guerendo could absorb more work behind SF's offense, with James looming as a rookie wildcard.

McCaffrey is the clear workhorse in SF's backfield; Kiner's presence behind him adds depth but limits immediate upside. Any long-term plan for Kiner hinges on McCaffrey’s workload, suspension of injuries, and SF’s usage of UDFA backs to supplement a power-running game.

McCaffrey is highlighted as a perennial fantasy engine, with history of elite efficiency and durability highlighted. The host notes his past two seasons, where health has been a gatekeeper for peak production, but with the 49ers’ system, his ceiling remains among the highest in fantasy football.

McCaffrey remains the clearest high-floor, high-ceiling back in standard formats, with dominant usage as lead back and receiving weapon in San Francisco. He offers a reliable baseline with explosive upside, making him one of the few players who can anchor a fantasy roster with little downside in non-PPR contexts.

McCaffrey remains SF’s primary offensive engine. Moore’s arrival adds speed and gadget options, but McCaffrey’s workload and versatility keep him as the centerpiece. Moore could open space for McCaffrey by drawing more defensive attention, but CMC still carries massive weekly upside.